Section 345IAC5-2-22. Genotypes of sheep

   (a) Two (2) locations on DNA that code for prion protein are particularly important for scrapie susceptibility and for the purposes of this article will be referred to as follows:

(1) Codon 136 that may code for the amino acids alanine (A) or valine (V).

(2) Codon 171 that may code for the amino acids arginine (R), glutamine (Q), histidine (H), or lysine (K).

For the purposes of this article, amino acids H, K, or any amino acid other than R at codon 171 will be treated as equivalent to Q at codon 171.

  (b) The abbreviations for amino acids alanine (A), valine (V), arginine (R), glutamine (Q), histidine (H), and lysine (K) apply throughout this article.

  (c) The following definitions of genetic types of sheep apply throughout this article:

(1) "RR sheep" means any sheep that has tested RR at codon 171 on an official genotype test.

(2) "QR sheep" means any sheep that has tested QR, KR, or HR at codon 171 on an official genotype test.

(3) "QQ sheep" means any sheep that has tested QQ, QK, QH, HK, KK, or HH at codon 171 on an official genotype test.

(4) "AV sheep" means any sheep that has tested AV at codon 136 on an official genotype test.

(5) "VV sheep" means any sheep that has tested VV at codon 136 on an official genotype test.

(6) "AA sheep" means any sheep that has tested AA at codon 136 on an official genotype test.

(7) "AA QR sheep" means any sheep that has tested QR, KR, or HR at codon 171 and AA at codon 136 on an official genotype test.

(8) "AV QR sheep" means any sheep that has tested QR, KR, or HR at codon 171 and AV at codon 136 on an official genotype test.

(9) "AA QQ sheep" means any sheep that has tested QQ, QK, QH, HK, KK, or HH at codon 171 and AA at codon 136 on an official genotype test.

(10) "AV QQ sheep" means any sheep that has tested QQ, QK, QH, HK, KK, or HH at codon 171 and AV at codon 136 on an official genotype test.

(11) "VV QQ sheep" means any sheep that has tested QQ, QK, QH, HK, KK, or HH at codon 171 and VV at codon 136 on an official genotype test.

  (d) The state veterinarian may require confirmatory testing before designating any animal a particular genetic class under subsection (c). (Indiana State Board of Animal Health; 345 IAC 5-2-22; filed Jan 5, 2006, 8:00 a.m.: 29 IR 1540; readopted filed Aug 16, 2012, 8:27 a.m.: 20120912-IR-345120197RFA)